Viral infection can lead to significant morbidity and mortality in patients with mitochondrial disease. The Metabolism, Infection and Immunity Section (MINI Section) of NHGRI takes a translational approach to understanding the role of the infection and immunity in mitochondrial diseases. The project for this position is focused on leveraging genomic technologies to better understand viral pathophysiology in mitochondrial disease. The successful candidate will employ innovative approaches to answer important questions in mitochondrial medicine: patient studies, PhiP-seq, RNA-seq, ATAC-seq, iPS cells, animal models, metabolomics, stable isotope flux, in vivo metabolic imaging, enzyme assays, immunohistochemistry, and bioenergetics studies.
We are seeking a highly motivated, creative and collaborative individual with a publication record, who is able to engage in independent reasoning and excited about integrating omic technologies to understand mechanisms of pathophysiology. Ideal candidates must have a Ph.D. and/or M.D. and < 5 years of postdoctoral training. Preference will be given to candidates who have experience with models of viral infection, viral pathophysiology, immunology, metabolism, and cell and molecular biology. Prior experience with PhiP-seq, metabolomics, extracellular flux analysis of bioenergetic function (Seahorse Biosciences) or high resolution respirometry (Oroboros) is a plus. The candidate should have excellent writing and communication skills.
If you are interested, please send a research statement, curriculum vitae, and the names and contact information of 3 references to:
Peter J. McGuire MS, MD
Metabolism, Infection and Immunity Section
National Human Genome Research Institute
National Institutes of Health
10 Center Drive
Bethesda, MD 20892
This post will be available until March 11, 2021 or until filled.
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